TIM3+FOXP3+regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer
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چکیده
منابع مشابه
TIM3+FOXP3+ regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer
T-cell immunoglobulin mucin 3 (TIM3) is an inhibitory molecule that has emerged as a key regulator of dysfunctional or exhausted CD8+ T cells arising in chronic diseases such as cancer. In addition to exhausted CD8+ T cells, highly suppressive regulatory T cells (Tregs) represent a significant barrier against the induction of antitumor immunity. We have found that the majority of intratumoral F...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2013
ISSN: 2162-402X
DOI: 10.4161/onci.23849